逸見百江先生の紹介

助教 逸見 百江 助教 逸見 百江
Momoe Itsumi Ph.D.
momomolv at tmd.ac.jp
Assistant Professor
つり

癌研究への挑戦

私は高校時代に出会った生命科学への興味が今も続いていることに自らも驚愕しています。そのおかげか、これまで私は、枠にとらわれず幅広くいろいろな分野で研究を行ってきました。再生医療の研究を行っていた学部時代、免疫学を学びだした大学院時代を経てカナダに渡り、細胞内での代謝の役割についての研究を行いました。そして帰国後、癌研究を始めました。この癌の研究は、生命科学に興味を持ちだした当初からの目標でもありました。私が学んできた分野は、各々に研究が進んでおり、今まではあまり交わることのない分野でした。しかし、近年の研究報告からも分かるように、これらの研究分野は根底では繋がっており、今後はあらゆる分野とのコラボレーションで研究は進んでいくものと考えています。現在、私はこれらの分野で学んだことを土台に新たな癌研究への挑戦を行っております。

免疫

代謝

がん

ガン細胞とは

正常な細胞がガン細胞になるとき

がん細胞予備軍は通常の生体の持つ機構により排除されている。

しかし、多くのがん細胞は生体の排除機構から回避することで生存を続けている。

密集したガン組織の中は低酸素状態であり生存に不利であるにもかかわらず生存している。

ガン細胞には自らdeath signalを誘導するような物質(TNFaなど)を産生しているものもいる。このような環境下でも生存している。

多くの研究がなされている今日のガンの分野に新しい視点からの研究を行うことを目的として日々取り組んでいます。

ガン細胞だけにとらわれず、ガン細胞を取り巻く環境などマクロな視点で研究を行いたいと思っている方、ぜひ一緒に研究してみませんか。

業績

原著論文

  • Tak W. Mak, Melanie Grusdat, Gordon S. Duncan, Catherine Dostert, Yannic Nonnenmacher, Maureen Cox,Carole Binsfeld, Zhenyue Hao, Anne Br€ustle, Momoe Itsumi, Christian J€ager, Ying Chen, Olaf Pinkenburg,B€arbel Camara, Markus Ollert,Carsten Bindslev-Jensen, Vasilis Vasiliou, Chiara Gorrini, Philipp A. Lang, Michael Lohoff, Isaac S. Harris, Karsten Hiller and Dirk Brenner. Glutathione Primes T Cell Metabolism for Inflammation. Immunity. 2017 Apr 18;46(4):675–689
  • Shiota M, Fujimoto N, Itsumi M, Takeuchi A, Inokuchi J, Tatsugami K, Yokomizo A, Kajioka S, Uchiumi T, Eto M.. Gene polymorphisms in antioxidant enzymes correlate with the efficacy of androgen-deprivation therapy for prostate cancer with implications of oxidative stress. Ann Oncol. 2016 Dec 19.pii: mdw646. [Epub ahead of print]
  • Masaaki Sugimoto · Kenichi Kohashi · Momoe Itsumi · Masaki Shiota · Tatsuro Abe · Yuichi Yamada · Kentaro Kuroiwa · Seiji Naito. Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features. Pathobiology. 2016 May 26;83(6):277-286.
  • Momoe Itsumi · Masaki Shiota · Ario Takeuchi · Eiji Kashiwagi · Junichi Inokuchi · Katsunori Tatsugami · Shunichi Kajioka · Takeshi Uchiumi · Seiji Naito · Masatoshi Eto · Akira Yokomizo. Equol inhibits prostate cancer growth via degradation of the androgen receptor by Skp2. Cancer Sci. 2016 Jul;107(7):1022-8.
  • Masaki Shiota · Momoe Itsumi · Ario Takeuchi · Kenjiro Imada · Akira Yokomizo · Hidetoshi Kuruma · Junichi Inokuchi · Katsunori Tatsugami · Takeshi Uchiumi · Yoshinao Oda · Seiji Naito · Masatoshi Eto. MP62-20 CROSSTALK BETWEEN ITHELIAL-MESENCHYMAL TRANSITION AND CASTRATION RESISTANCE IN PROSTATE CANCER. Endocr Relat Cancer. 2015 Dec;22(6):889-900.
  • Masaki Shiota · Momoe Itsumi · Ario Takeuchi · Kenjiro Imada · Akira Yokomizo · Hidetoshi Kuruma · Junichi Inokuchi · Katsunori Tatsugami · Takeshi Uchiumi · Yoshinao Oda · Seiji Naito. Crosstalk between EMT and castration resistance mediated by Twist1/AR signaling in prostate cancer. Endocr Relat Cancer. 2015 Dec;22(6):889-900.
  • Masaki Shiota, Naohiro Fujimoto, Akira Yokomizo, Ario Takeuchi, Momoe Itsumi, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Naito. SRD5A gene polymorphism in Japanese men predicts prognosis of metastatic prostate cancer with androgen-deprivation therapy. Eur J Cancer. 2015 Sep;51(14):1962-9.
  • Maya Hayashi, Shunichi Kajioka, Momoe Itsumi, Ryosuke Takahashi, Nouval Shahab, Takao Ishigami, Masahiro Takeda, Noriyuki Masuda, Akito Yamaguchi, Seiji Naito. Actions of cyclic 3'5’-adenosine monophosphate (cAMP) on calcium sensitisation in human detrusor smooth muscle contraction. BJU International. 2016 Jan;117(1):179-91.
  • M Itsumi, S Inoue, A J Elia, K Murakami, M Sasaki, E F Lind, D Brenner, I S Harris, I I C Chio, S Afzal, R A Cairns, D W Cescon, A R Elford, J Ye, P A Lang, W Y Li, A Wakeham, G S Duncan, J Haight, A You-Ten, B Snow, K Yamamoto, P S Ohashi, T W Mak. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio. Cell Death and Differentiation. 2015 Nov;22(11):1837-45. 2015
  • Samia Afzala, Zhenyue Hao, Momoe Itsumi, Yasser Abouelkheer, Dirk Brenner, Yunfei Gao, Andrew Wakeham, Claire Hong, Wanda Y. Li, Jennifer Sylvester, Syed O. Gilani, Anne Brüstle, Jillian Haight, Annick J. You-Ten, Gloria H. Y. Lin, Satoshi Inoue, Tak W. Mak. Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis. Proceedings of the National Academy of Sciences. 2015 Jan 27;112(4):1119-24.
  • Ario Takeuchi, Masatoshi Eto, Katsunori Tatsugami, Hisakata Yamada, Akira Yokomizo, Masaki Shiota, Momoe Itsumi, Junichi Inokuchi, Keijiro Kiyoshima, Takashi Dejima, Kenjiro Imada, Seiji Naito, Yasunobu Yoshikai. Renal cancer treatment with recipient lymphocyte infusion enhanced the antitumor effect of nonmyeloablative allogeneic stem cell transplantation. Transplant Immunology. 2015 Mar;32(2):131-9
  • Masaki Shiota, Momoe Itsumi, Akira Yokomizo, Ario Takeuchi, Kenjiro Imada, Eiji Kashiwagi, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Naito. Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer. The Prostate. 2014 Jun;74(8):829-38
  • Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Momoe Itsumi, Kenjiro Imada, Eiji Kashiwagi, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Naito. Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer. The Prostate. 2014 Jun;74(9):959-69.
  • Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Eiji Kashiwagi, Takashi Dejima, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Naito. Androgen receptor downregulation and cellular apoptosis by PMA in prostate cancer cells. Journal of Molecular Endocrinology. 2014 Aug;53(1):31-41.
  • Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, Haight J, Wakeham A, Shahinian A, Ikura M, Topisirovic I, Sonenberg N, Mak TW. Largen: A Molecular Regulator of Mammalian Cell Size Control. Molecular cell. 2014 Mar 20;53(6):904-15.
  • Inoue S1, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes & development. 2013 May 15;27(10):1101-14.
  • Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Eiji Kashiwagi, Ario Takeuchi, Katsunori Tatsugami, Junichi Inokuchi, Yoohyun Song, Takeshi Uchiumi, Seiji Naito. Human heterochromatin protein 1 isoforms regulate androgen receptor signaling in prostate cancer. Journal of Molecular Endocrinology. 2013 Apr 23;50(3):401-9.
  • Eiji Kashiwagi, Masaki Shiota, Akira Yokomizo, Junichi Inokuchi, Momoe Itsumi, Takeshi Uchiumi, Seiji Naito. Prostaglandin receptor EP3 mediates growth inhibitory effect of aspirin through androgen receptor and contributes to castration resistance in prostate cancer cells. Endocrine Related Cancer. 2013 May 30;20(3):431-41.
  • Ario Takeuchi, Masaki Shiota, Katsunori Tatsugami, Akira Yokomizo, Kentaro Kuroiwa, Takashi Dejima, Shingo Tanaka, Momoe Itsumi, Masatoshi Eto, Seiji Naito. YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α. Cancer Immunology and Immunotherapy. 2013 Mar;62(3):517-27.
  • Masato Sasaki, Christiane B Knobbe, Momoe Itsumi, Andrew J Elia, Isaac S Harris, Iok In Christine Chio, Rob A Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine E Yen, Shinsan M Su, Tak Wah Mak. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes & development 2012 Sep 15;26(18):2038-49.
  • Eiji Kashiwagi, Masaki Shiota, Akira Yokomizo, Momoe Itsumi, Junichi Inokuchi, Takeshi Uchiumi, Seiji Naito. Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer. The Prostate. 2012 May 15;72(7):741-51.
  • Ario Takeuchi, Masatoshi Eto, Masaki Shiota, Katsunori Tatsugami, Akira Yokomizo, Kentaro Kuroiwa, Momoe Itsumi, Seiji Naito. Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1/2 phosphorylation. International Journal of Oncology. 2012 May;40(5):1691-6.
  • Takeshi Uchiumi, Yasuhiro Tada, YooHyun Song, Eiji Kashiwagi, Daisuke Masubuchi, Seiji Naito. Twist1 and Y-box-binding protein-1 promote malignant potential in bladder cancer cells. BJU International. 2011 Jul;108(2 Pt 2):E142-9.
  • Masaki Shiota, Masatoshi Eto, Akira Yokomizo, Yasuhiro Tada, Ario Takeuchi, Momoe Itsumi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Naito. Sensitivity of doxorubicin-resistant cells to sorafenib: possible role for inhibition of eukaryotic initiation factor-2alpha phosphorylation. International Journal of Oncology. 2010 Aug;37(2):509-17.
  • Shino Kumabe, Momoe Itsumi, Hisakata Yamada, Toshiki Yajima, Tetsuya Matsuguchi, Yasunobu Yoshikai. Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells. Microbiology and Immunology 2010 Feb;54(2):105-11
  • Akiko Oyamada, Hiori Ikebe, Momoe Itsumi, Hirokazu Saiwai, Seiji Okada, Kazuya Shimoda, Yoichiro Iwakura, Keiichi I Nakayama, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada. Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis. The Journal of Immunology. 2009 Dec 1;183(11):7539-46.
  • Momoe Itsumi, Yasunobu Yoshikai, Hisakata Yamada. IL-15 is critical for the maintenance and innate functions of self-specific CD8+ T cells. European Journal of Immunology. 2009 Jul;39(7):1784-93.
  • Kensuke Shibata, Hisakata Yamada, Risa Nakamura, Xun Sun, Momoe Itsumi, Yasunobu Yoshikai. Identification of CD25+ γδ T cells as fetal thymus-derived naturally occurring IL-17 producers. The Journal of Immunology. 2008 Nov;181(9):5940-5947

総説・著書

  • Momoe Itsumi, Katsunori Tatsugami. Immunotherapy for Renal Cell Carcinoma. Clinical and Developmental Immunology. 2012 Sep;23 Suppl 8:viii35-40.