Project

Microbiology covers several aspects of bacteriology, immunology and virology. Through the studies on various microbes it is expected to understand host-parasite relationship and mechanisms of pathogenicity. Unlike the past, microbiology has rapidly been drawn to the center of the medical sciences.

Our laboratory mainly deals with viral oncogenesis and immunodeficiency of the man. Especially, several projects are carried out with the emphasis on investigation into the mechanisms of viral replication and pathogenesis induced by human retroviruses (HIV-1 and HTLV-I) and human herpesviruses. The purpose of many of the studies being undertaken is to identify critical events and molecules responsible for the efficient replication of these viruses, and in case of human retroviruses resulting transformation or destruction of normal lymphocytes. Virological, immunological and molecular approaches are being applied for this purpose.

 

Undergraduate education:

Understand principles underlying the structures, growth, functions. genetics of microbe itself, and their interactions with human body through educations in lectures and courses.

 

Postgraduate course:

Identify the truly vital roots of classical as well as modern bacteriology, immunology and virology, and to engraft upon them the recent molecular advances. Understand how scientific advances may depend on new concepts of techniques, or on ingenious experiments, or on alertness to the significance of unexpected observations.

 

Research subjects:

Following studies have been extensively carried our in out laboratory with various biological and molecular biological techniques:

  1. Pathogenesis of HIV (mutation, virulence, apoptosis, gene expression profiling, animal model).
  2. Host factors regulating HIV replication.
  3. Studies on NF-kappaB activation by HTLV-I Tax and Epstein-Barr virus LMP1.
  4. Studies on signal transduction events leading to constitutive NF-kappaB activation.